Hyemin Gu

Postdoctoral Researcher at Mathematics and Statistics, University of Massachusetts Amherst.

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I am a postdoctoral researcher in Markos Katsoulakis’s group at UMass Amherst, where I completed my Ph.D. in Applied Mathematics with the dissertation Robust Generative Modeling with Wasserstein Proximal Regularization. My research places machine learning models on mathematical foundations, so that their behavior can be predicted, analyzed, and controlled through the underlying theory.

Research interests. Mathematically grounded machine learning; generative modeling; stable learning algorithms; dynamical systems; scientific applications of machine learning.

My work centers on

  • formulating well-posed learning objectives for generative modeling and dynamical systems through optimal-transport, mean-field-game, and optimal-control principles;
  • developing stable learning algorithms through regularizations such as Wasserstein-1 / Wasserstein-2 proximal and Lipschitz regularization; and
  • translating these principles into scalable algorithms for scientific applications, including single-cell dynamics and supply-chain networks.

Under DARPA’s The Right Space program, I am developing principled machine learning architectures for complex learning and optimization, together with dynamical-system simulators for supply-chain networks. This includes stable residual neural architectures characterized through Hamilton–Jacobi and optimal-control formulations, and ISOMORPH, a Markov-chain-based digital twin of multi-echelon logistics networks for scalable simulation and forecasting benchmarks. In parallel, I lead the mathematical and algorithmic development of PROFET, a gradient-flow-based generative framework for continuous trajectory inference from sparse scRNA-seq data.

A recurring challenge in mathematical sciences is balancing abstraction, which enables transferability across domains, with concrete problem formulations, which often drive practical advances. My long-term goal is to let mathematical theory and real-world applications continuously inform and strengthen one another.

news

Jul 16, 2026 Preprint released: Sharp Stability Threshold and Certification for Designing Stable Residual Architectures.
Jun 24, 2026 PROFET, our gradient-flow-based generative framework for continuous single-cell trajectory inference, was accepted at Cell Systems.
May 12, 2026 Preprint released: ISOMORPH: A Supply Chain Digital Twin for Simulation, Dataset Generation, and Forecasting Benchmarks — with an interactive demonstration platform.

selected publications

  1. Stable-ResNet
    Sharp Stability Threshold and Certification for Designing Stable Residual Architectures
    Hyemin Gu, Michael Tyrrell, Tuhin Sahai, and Markos A. Katsoulakis
    2026
  2. PROFET
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    PROFET Predicts Continuous Gene Expression Dynamics from scRNA-seq Data to Elucidate Heterogeneity of Cancer Treatment Responses
    Yu-Chen Cheng, Hyemin Gu, Markos A. Katsoulakis, Franziska Michor, and  others
    Cell Systems, accepted, 2026
  3. ISOMORPH
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    ISOMORPH: A Supply Chain Digital Twin for Simulation, Dataset Generation, and Forecasting Benchmarks
    Zhizhen Zhang, Hyemin Gu, Markos A. Katsoulakis, Tuhin Sahai, and  others
    2026
  4. GPA
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    Lipschitz-Regularized Gradient Flows and Generative Particle Algorithms for High-Dimensional Scarce Data
    Hyemin Gu, Panagiota Birmpa, Yannis Pantazis, Luc Rey-Bellet, and Markos A. Katsoulakis
    SIAM Journal on Mathematics of Data Science, 2024